Transforming Growth Factor β-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

Transforming growth factor β-activated kinase 1 (TAK1) kinase is an indispensable signaling intermediate in tumor necrosis factor (TNF), interleukin 1, and Toll-like receptor signaling pathways. TAK1-binding protein 2 (TAB2) and its closely related protein, TAB3, are binding partners of TAK1 and hav...

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Autores principales: Broglie, Peter, Matsumoto, Kunihiro, Akira, Shizuo, Brautigan, David L., Ninomiya-Tsuji, Jun
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807291/
https://ncbi.nlm.nih.gov/pubmed/19955178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.090522
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