Chitosan IFN-γ-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma

BACKGROUND: Allergic subjects produce relatively low amounts of IFN-γ, a pleiotropic Th-1 cytokine that downregulates Th2-associated airway inflammation and hyperresponsiveness (AHR), the hallmarks of allergic asthma. Adenovirus-mediated IFN-γ gene transfer reduces AHR, Th2 cytokine levels and lung...

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Autori principali: Kumar, Mukesh, Kong, Xiaoyuan, Behera, Aruna K, Hellermann, Gary R, Lockey, Richard F, Mohapatra, Shyam S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2003
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC280670/
https://ncbi.nlm.nih.gov/pubmed/14613519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-1-3
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