A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3

Infection by Toxoplasma gondii down-regulates the host innate immune responses, such as proinflammatory cytokine production, in a Stat3-dependent manner. A forward genetic approach recently demonstrated that the type II strain fails to suppress immune responses because of a potential defect in a hig...

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Main Authors: Yamamoto, Masahiro, Standley, Daron M., Takashima, Seiji, Saiga, Hiroyuki, Okuyama, Megumi, Kayama, Hisako, Kubo, Emi, Ito, Hiroshi, Takaura, Mutsumi, Matsuda, Tadashi, Soldati-Favre, Dominique, Takeda, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806617/
https://ncbi.nlm.nih.gov/pubmed/19901082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091703
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