Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells

Semen is the main vector for HIV-1 dissemination worldwide. It contains three major sources of infectious virus: free virions, infected leukocytes, and spermatozoa-associated virions. We focused on the interaction of HIV-1 with human spermatozoa and dendritic cells (DCs). We report that heparan sulf...

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Main Authors: Ceballos, Ana, Remes Lenicov, Federico, Sabatté, Juan, Rodríguez Rodrígues, Christian, Cabrini, Mercedes, Jancic, Carolina, Raiden, Silvina, Donaldson, Mónica, Agustín Pasqualini, Rodolfo, Marin-Briggiler, Clara, Vazquez-Levin, Mónica, Capani, Francisco, Amigorena, Sebastián, Geffner, Jorge
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806607/
https://ncbi.nlm.nih.gov/pubmed/19858326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091579
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