Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

The double-stranded RNA (dsRNA) analogue poly(I:C) is a promising adjuvant for cancer vaccines because it activates both dendritic cells (DCs) and natural killer (NK) cells, concurrently promoting adaptive and innate anticancer responses. Poly(I:C) acts through two dsRNA sensors, Toll-like receptor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McCartney, Stephen, Vermi, William, Gilfillan, Susan, Cella, Marina, Murphy, Theresa L., Schreiber, Robert D., Murphy, Kenneth M., Colonna, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2009
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806445/
https://ncbi.nlm.nih.gov/pubmed/19995959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091181
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