The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells

PURPOSE: Glioblastoma multiforme (GBM) is resistant to current cytotoxic therapies, in part because of enhanced DNA repair. Activation of the receptor tyrosine kinase c-Met has been shown to protect cancer cells from DNA damage. We hypothesized that inhibiting c-Met would decrease this protection an...

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Main Authors: Welsh, James W, Mahadevan, Daruka, Ellsworth, Ron, Cooke, Laurence, Bearss, David, Stea, Baldassarre
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806296/
https://ncbi.nlm.nih.gov/pubmed/20028557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-4-69
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