Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

BACKGROUND: Saccharomyces cerevisiae BY4741 is an auxotrophic commonly used strain. In this work it has been used as host for the expression and secretion of human interleukin-1β (IL1β), using the cell wall protein Pir4 as fusion partner. To achieve high cell density and, consequently, high product...

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Détails bibliographiques
Auteurs principaux: Paciello, Lucia, de Alteriis, Elisabetta, Mazzoni, Cristina, Palermo, Vanessa, Zueco, Jesus, Parascandola, Palma
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2009
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806294/
https://ncbi.nlm.nih.gov/pubmed/20042083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-8-70
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