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Rational Design of Inhibitors of VirA-VirG Two-Component Signal Transduction
VirA-VirG two-component system regulates the vir (virulence) operon in response specific host factors (xenognosins) in the plant pathogen A. tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806187/ https://ncbi.nlm.nih.gov/pubmed/17470391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.04.018 |
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