Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family

Rottlerin is a polyphenolic compound derived from Mallotus philipinensis. In the present study, we show that rottlerin decreased tumor size and stimulated apoptosis in an orthotopic model of pancreatic cancer with no effect on normal tissues in vivo. Rottlerin also induced apoptosis in pancreatic ca...

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Hauptverfasser: Ohno, Izumi, Eibl, Guido, Odinokova, Irina, Edderkaoui, Mouad, Damoiseaux, Robert D., Yazbec, Moussa, Abrol, Ravinder, Goddard, William A., Yokosuka, Osamu, Pandol, Stephen J., Gukovskaya, Anna S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
Schlagworte:
Hormones and Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806098/
https://ncbi.nlm.nih.gov/pubmed/19762431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00257.2009
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