Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family

Rottlerin is a polyphenolic compound derived from Mallotus philipinensis. In the present study, we show that rottlerin decreased tumor size and stimulated apoptosis in an orthotopic model of pancreatic cancer with no effect on normal tissues in vivo. Rottlerin also induced apoptosis in pancreatic ca...

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Detalhes bibliográficos
Main Authors: Ohno, Izumi, Eibl, Guido, Odinokova, Irina, Edderkaoui, Mouad, Damoiseaux, Robert D., Yazbec, Moussa, Abrol, Ravinder, Goddard, William A., Yokosuka, Osamu, Pandol, Stephen J., Gukovskaya, Anna S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Hormones and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806098/
https://ncbi.nlm.nih.gov/pubmed/19762431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00257.2009
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