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Calorie restriction reduces rDNA recombination independently of rDNA silencing
Calorie restriction (CR) extends lifespan in yeast, worms, flies and mammals, suggesting that it acts via a conserved mechanism. In yeast, activation of the NAD-dependent histone deacetylase, Sir2, by CR is thought to increase silencing at the ribosomal DNA, thereby reducing the recombination-induce...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805862/ https://ncbi.nlm.nih.gov/pubmed/19732046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00514.x |
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