Hereditary thrombocytosis caused by MPL(Ser505Asn) is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis

BACKGROUND: The MPL(Ser505Asn) mutation has been reported to be a cause of hereditary thrombocythemia. Recently, we detected this mutation in a large proportion of children with familial thrombocythemia, suggesting that in Italy the incidence of MPL(Ser505Asn) mutation could be underestimated. DESIG...

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Hoofdauteurs: Teofili, Luciana, Giona, Fiorina, Torti, Lorenza, Cenci, Tonia, Ricerca, Bianca Maria, Rumi, Carlo, Nunes, Vittorio, Foà, Robin, Leone, Giuseppe, Martini, Maurizio, Larocca, Luigi Maria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ferrata Storti Foundation 2010
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805752/
https://ncbi.nlm.nih.gov/pubmed/19713221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.007542
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