rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is the third major locus affecting risk of type I diabetes (T1D), after HLA-DR/DQ and INS. The most associated single-nucleotide polymorphism (SNP), rs2476601, has a C->T variant and results in an arginine (R) to tryptophan (W) amino acid...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Steck, AK, Baschal, EE, Jasinski, JM, Boehm, BO, Bottini, N, Concannon, P, Julier, C, Morahan, G, Noble, JA, Polychronakos, C, She, JX, Eisenbarth, GS
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805459/
https://ncbi.nlm.nih.gov/pubmed/19956096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2009.87
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki