Titration of Variant HSV1-tk Gene Expression to Determine the Sensitivity of (18)F-FHBG PET Imaging in a Prostate Tumor

Because of its high selectivity and specificity for the imaging reporter probe 9-(4-(18)F-fluoro-3-[hydroxymethyl]butyl)guanine ((18)F-FHBG), the herpes simplex virus type 1 thymidine kinase (HSV1-tk) variant sr39tk is actively being studied as a PET reporter gene. We recently demonstrated the capab...

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Autors principals: Johnson, Mai, Karanikolas, Breanne D.W., Priceman, Saul J., Powell, Russell, Black, Margaret E., Wu, Hsiao-Ming, Czernin, Johannes, Huang, Sung-Cheng, Wu, Lily
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805178/
https://ncbi.nlm.nih.gov/pubmed/19372484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.058438
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