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Lung cancer patients’ CD4(+) T cells are activated in vitro by MHC II cell-based vaccines despite the presence of myeloid-derived suppressor cells

BACKGROUND: Advanced non-small cell lung cancer (NSCLC) remains an incurable disease. Immunotherapies that activate patients’ T cells against resident tumor cells are being developed; however, these approaches may not be effective in NSCLC patients due to tumor-induced immune suppression. A major ca...

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Main Authors: Srivastava, Minu K., Bosch, Jacobus J., Thompson, James A., Ksander, Bruce R., Edelman, Martin J., Ostrand-Rosenberg, Suzanne
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805175/
https://ncbi.nlm.nih.gov/pubmed/18322683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0490-9
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