Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma

BACKGROUND: Trimethylation of lysine 27 on histone H3 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that mediates gene silencing. EZH2 is overexpressed and correlates with poor prognosis in many cancers. However, the clinical implication of H3K27me3 in human malignancies has...

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Bibliografiske detaljer
Main Authors: He, Li-Ru, Liu, Meng-Zhong, Li, Bin-Kui, Rao, Hui-Lan, Liao, Yi-Ji, Guan, Xin-Yuan, Zeng, Yi-Xin, Xie, Dan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804715/
https://ncbi.nlm.nih.gov/pubmed/20028503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-461
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