A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

A full-length cDNA for the human multidrug resistance gene 1 (MDR1) has been inserted into a retroviral vector containing a murine Harvey sarcoma virus from which the viral oncogene was deleted. Ecotropic and amphotropic virus was produced after transfection of this vector into psi-2 and PA-12 packa...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Pastan, I, Gottesman, M M, Ueda, K, Lovelace, E, Rutherford, A V, Willingham, M C
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1988
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2898143/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4486
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