HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN)

In this study, we identify determinants in dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) necessary for human immunodeficiency virus, type 1 (HIV-1), transmission. Although human B cell lines expressing DC-SIGN efficiently capture and transmit HIV-1 to susceptible target cells, cells...

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Hauptverfasser: Chung, Nancy P. Y., Breun, Sabine K. J., Bashirova, Arman, Baumann, Joerg G., Martin, Thomas D., Karamchandani, Jaideep M., Rausch, Jason W., Le Grice, Stuart F. J., Wu, Li, Carrington, Mary, KewalRamani, Vineet N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804366/
https://ncbi.nlm.nih.gov/pubmed/19833723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030619
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