N-Linked Glycosylation Is Essential for the Stability but Not the Signaling Function of the Interleukin-6 Signal Transducer Glycoprotein 130

N-Linked glycosylation is an important determinant of protein structure and function. The interleukin-6 signal transducer glycoprotein 130 (gp130) is a common co-receptor for cytokines of the interleukin (IL)-6 family and is N-glycosylated at 9 of 11 potential sites. Whereas N-glycosylation of the e...

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Autori principali: Waetzig, Georg H., Chalaris, Athena, Rosenstiel, Philip, Suthaus, Jan, Holland, Christin, Karl, Nadja, Vallés Uriarte, Lorena, Till, Andreas, Scheller, Jürgen, Grötzinger, Joachim, Schreiber, Stefan, Rose-John, Stefan, Seegert, Dirk
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804336/
https://ncbi.nlm.nih.gov/pubmed/19915009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075952
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