Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.
The conversion of cells from a normal phenotype to full malignancy apparently requires multiple genetic events. Efforts to reconstruct multistep tumorigenesis in cell culture have shown that two types of oncogenes (typified by HRAS and MYC) can cooperate to elicit complete transformation. Transforma...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1988
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3132710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.12.4355 |
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