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Up-regulation of γ-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity: Implications for Parkinson’s disease

Up-regulation of activity of γ-glutamyl transpeptidase (GGT) has been reported to occur in the Parkinsonian substantia nigra, the area of the brain affected by the disease. Increased GGT activity has been hypothesized to play a role in subsequent mitochondrial complex I (CI) inhibition by increasing...

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Bibliografski detalji
Glavni autori: Chinta, Shankar J., Kumar, Jyothi M., Zhang, Hongqiao, Forman, Henry Jay, Andersen, Julie K.
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804072/
https://ncbi.nlm.nih.gov/pubmed/16632116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2005.12.023
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