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3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

An excess of the tryptophan metabolite quinolinic acid in the brain has been hypothetically related to the pathogenesis of Huntington disease. Quinolinate's immediate biosynthetic enzyme, 3-hydroxyanthranilate oxygenase (EC 1.13.11.6), has now been detected in human brain tissue. The activity o...

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Main Authors: Schwarcz, R, Okuno, E, White, R J, Bird, E D, Whetsell, W O
Format: Artigo
Jezik:Inglês
Izdano: 1988
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC280365/
https://ncbi.nlm.nih.gov/pubmed/2967497
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