Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent.

Technetium-99m labeling of antibodies has been suboptimal because of low affinity adventitious binding, nonspecific labeling, and loss of immunoreactivity. The diamide dithiolate ligand system (N2S2) forms highly stable, well-defined tetradentate complexes with Tc(V). Antibodies and their fragments...

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Detalhes bibliográficos
Main Authors: Fritzberg, A R, Abrams, P G, Beaumier, P L, Kasina, S, Morgan, A C, Rao, T N, Reno, J M, Sanderson, J A, Srinivasan, A, Wilbur, D S
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC280353/
https://ncbi.nlm.nih.gov/pubmed/3375252
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