HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

BACKGROUND: The response rate of ovarian mucinous carcinomas to paclitaxel/carboplatin is low, prompting interest in targeted molecular therapies. We investigated HER2 expression and amplification, and the potential for trastuzumab therapy in this histologic subtype of ovarian cancer. METHODS: HER2...

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Detalhes bibliográficos
Main Authors: McAlpine, Jessica N, Wiegand, Kimberly C, Vang, Russell, Ronnett, Bridgett M, Adamiak, Anna, Köbel, Martin, Kalloger, Steve E, Swenerton, Kenneth D, Huntsman, David G, Gilks, C Blake, Miller, Dianne M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803495/
https://ncbi.nlm.nih.gov/pubmed/20003286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-433
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