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Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole

Glycolate oxidase, a peroxisomal flavoenzyme, generates glyoxylate at the expense of oxygen. When the normal metabolism of glyoxylate is impaired by the mutations that are responsible for the genetic diseases hyperoxaluria types 1 and 2, glyoxylate yields oxalate, which forms insoluble calcium depos...

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Detalhes bibliográficos
Main Authors: Bourhis, Jean-Marie, Vignaud, Caroline, Pietrancosta, Nicolas, Guéritte, Françoise, Guénard, Daniel, Lederer, Florence, Lindqvist, Ylva
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802872/
https://ncbi.nlm.nih.gov/pubmed/20054120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109041670
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