Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.

Poliovirus exists as three stable serotypes (PV-1, PV-2, and PV-3). These viruses display three antigenic sites each, designated N-AgI, N-AgII, and N-AgIII. When mice are immunized with poliovirus, N-AgI is the major neutralization antigenic site for PV-3, whereas N-AgII and N-AgIII are immunodomina...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Murray, M G, Kuhn, R J, Arita, M, Kawamura, N, Nomoto, A, Wimmer, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2834736/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.9.3203
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