Conversion of encapsulated 5-fluoro-2'-deoxyuridine 5'-monophosphate to the antineoplastic drug 5-fluoro-2'-deoxyuridine in human erythrocytes.

The fluoropyrimidine deoxyribonucleotide 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) was encapsulated in human erythrocytes by a procedure based on hypotonic hemolysis and isotonic resealing. Encapsulated FdUMP (up to 9 mumol/ml of packed erythrocytes) did not affect erythrocyte meta...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: De Flora, A, Zocchi, E, Guida, L, Polvani, C, Benatti, U
Format: Artigo
Langue:Inglês
Publié: 1988
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC280160/
https://ncbi.nlm.nih.gov/pubmed/2966399
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