The Short-Chain Fatty Acid Methoxyacetic Acid Disrupts Endogenous Estrogen Receptor-α–Mediated Signaling

BACKGROUND: Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. OBJECTIVE: Because estrogen sign...

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Main Authors: Henley, Derek V., Mueller, Stephanie, Korach, Kenneth S.
Formato: Artigo
Idioma:Inglês
Publicado: National Institute of Environmental Health Sciences 2009
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801194/
https://ncbi.nlm.nih.gov/pubmed/20049119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0900800
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