Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits. Because several of these abnormalities occur in other disease states associated with alterations in aminergic neurotransmitters, we investigated the contribution of such alterations to RTT pathogenesis. We fo...

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Main Authors: Samaco, Rodney C., Mandel-Brehm, Caleigh, Chao, Hsiao-Tuan, Ward, Christopher S., Fyffe-Maricich, Sharyl L., Ren, Jun, Hyland, Keith, Thaller, Christina, Maricich, Stephen M., Humphreys, Peter, Greer, John J., Percy, Alan, Glaze, Daniel G., Zoghbi, Huda Y., Neul, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799790/
https://ncbi.nlm.nih.gov/pubmed/20007372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912257106
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