Identification of mutant monoclonal antibodies with increased antigen binding.

Sib selection and an ELISA have been used to isolate hybridoma subclones producing mutant antibodies that bind antigen better than the parental monoclonal antibody. Such mutants arise spontaneously in culture at frequencies of 2.5-5 X 10(-5). The sequences of the heavy and light chain variable regio...

詳細記述

書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Pollock, R R, French, D L, Gefter, M L, Scharff, M D
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1988
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3267219/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.7.2298
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