A Multidimensional Strategy to Detect Polypharmacological Targets in the Absence of Structural and Sequence Homology

Conventional drug design embraces the “one gene, one drug, one disease” philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that exhibit incr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Durrant, Jacob D., Amaro, Rommie E., Xie, Lei, Urbaniak, Michael D., Ferguson, Michael A. J., Haapalainen, Antti, Chen, Zhijun, Di Guilmi, Anne Marie, Wunder, Frank, Bourne, Philip E., McCammon, J. Andrew
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2010
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799658/
https://ncbi.nlm.nih.gov/pubmed/20098496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000648
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