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Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

Alginate matrix tablet of diltiazem hydrochloride (DTZ), a water-soluble drug, was prepared using sodium alginate (SAL) and calcium gluconate (CG) by the conventional wet granulation method for sustained release of the drug. The effect of formulation variables like SAL/CG ratio, drug load, microenvi...

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Detalhes bibliográficos
Main Authors: Mandal, Sanchita, Basu, Sanat Kumar, Sa, Biswanath
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799599/
https://ncbi.nlm.nih.gov/pubmed/19911286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-009-9333-z
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