Effect of Leucovorin (Folinic Acid) on the Developmental Quotient of Children with Down's Syndrome (Trisomy 21) and Influence of Thyroid Status

BACKGROUND: Seven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down's syndrome (DS). METHODOLOGY: We investigated the effect of oral folate supplementation (daily dose of 1.0±0.3 mg/k...

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Détails bibliographiques
Auteurs principaux: Blehaut, Henri, Mircher, Clotilde, Ravel, Aimé, Conte, Martine, de Portzamparc, Veronique, Poret, Gwendael, Huon de Kermadec, Françoise, Rethore, Marie-Odile, Sturtz, Franck G.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799517/
https://ncbi.nlm.nih.gov/pubmed/20084109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008394
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