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Activation of p53 Promotes Renal Injury in Acute Aristolochic Acid Nephropathy
Ingestion of aristolochic acid (AA) can cause AA nephropathy (AAN), in which excessive death of tubular epithelial cells (TECs) characterize the acute phase. AA forms adducts with DNA, which may lead to TEC apoptosis via p53-mediated signaling. We tested this hypothesis both by studying p53-deficien...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799275/ https://ncbi.nlm.nih.gov/pubmed/19892935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008111133 |
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