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Chronic Mineral Dysregulation Promotes Vascular Smooth Muscle Cell Adaptation and Extracellular Matrix Calcification

In chronic kidney disease (CKD) vascular calcification occurs in response to deranged calcium and phosphate metabolism and is characterized by vascular smooth muscle cell (VSMC) damage and attrition. To gain mechanistic insights into how calcium and phosphate mediate calcification, we used an ex viv...

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Detalles Bibliográficos
Main Authors: Shroff, Rukshana C., McNair, Rosamund, Skepper, Jeremy N., Figg, Nichola, Schurgers, Leon J., Deanfield, John, Rees, Lesley, Shanahan, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799273/
https://ncbi.nlm.nih.gov/pubmed/19959717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009060640
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