Carboplatin and Paclitaxel in Combination With Either Vorinostat or Placebo for First-Line Therapy of Advanced Non–Small-Cell Lung Cancer

PURPOSE: Vorinostat, a histone deacetylase inhibitor, exerts anticancer effects by both histone and nonhistone–mediated mechanisms. It also enhances the anticancer effects of platinum compounds and taxanes in non–small-cell lung cancer (NSCLC) cell lines. This phase II randomized, double-blinded, pl...

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Detalhes bibliográficos
Main Authors: Ramalingam, Suresh S., Maitland, Michael L., Frankel, Paul, Argiris, Athanassios E., Koczywas, Marianna, Gitlitz, Barbara, Thomas, Sachdev, Espinoza-Delgado, Igor, Vokes, Everett E., Gandara, David R., Belani, Chandra P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799233/
https://ncbi.nlm.nih.gov/pubmed/19933908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.24.9094
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