Detecting BRCA2 Protein Truncation in Tissue Biopsies to Identify Breast Cancers That Arise in BRCA2 Gene Mutation Carriers

PURPOSE: Mutations in the BRCA2 gene are dominantly inherited but cause cancers when the wild-type allele has loss of heterozygosity (LOH) within the cancer. Because most disease-associated BRCA2 mutations are protein-truncating mutations, a test for truncated BRCA2 proteins should identify most BRC...

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Detaylı Bibliyografya
Asıl Yazarlar: Watson, Patrice, Lieberman, Rita, Snyder, Carrie, Clark, Vanessa J., Lynch, Henry T., Holt, Jeffrey T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Clinical Oncology 2009
Konular:
Original Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799150/
https://ncbi.nlm.nih.gov/pubmed/19620486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.20.5211
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