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Multicenter, Phase I, Dose-Escalation Trial of Lenalidomide Plus Bortezomib for Relapsed and Relapsed/Refractory Multiple Myeloma

PURPOSE: Lenalidomide and bortezomib are active in relapsed and relapsed/refractory multiple myeloma (MM). In preclinical studies, lenalidomide sensitized MM cells to bortezomib and dexamethasone. This phase I, dose-escalation study (ie, NCT00153933) evaluated safety and determined the maximum-toler...

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Main Authors: Richardson, Paul G., Weller, Edie, Jagannath, Sundar, Avigan, David E., Alsina, Melissa, Schlossman, Robert L., Mazumder, Amitabha, Munshi, Nikhil C., Ghobrial, Irene M., Doss, Deborah, Warren, Diane L., Lunde, Laura E., McKenney, Mary, Delaney, Carol, Mitsiades, Constantine S., Hideshima, Teru, Dalton, William, Knight, Robert, Esseltine, Dixie-Lee, Anderson, Kenneth C.
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2799050/
https://ncbi.nlm.nih.gov/pubmed/19786667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.22.2679
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