N-ethyl-N-nitrosourea-induced null mutation at the mouse Car-2 locus: an animal model for human carbonic anhydrase II deficiency syndrome.

Electrophoretic screening of (C57BL/6J x DBA/2J)F1 progeny of male mice treated with N-ethyl-N-nitrosourea revealed a mouse that lacked the paternal carbonic anhydrase II (CA II). Breeding tests showed that this trait was heritable and due to a null mutation at the Car-2 locus on chromosome 3. Like...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lewis, S E, Erickson, R P, Barnett, L B, Venta, P J, Tashian, R E
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1988
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3126501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.6.1962
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