Neoplastic transformation inactivates specific trans-acting factor(s) required for the expression of the thyroglobulin gene.
The expression of rat thyroglobulin gene is repressed following the transformation of rat thyroid cells with Kirsten murine sarcoma virus. The expression of a reporter gene fused to the thyroglobulin promoter is down-regulated in transformed thyroid cells in transient or in stable transfection assay...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1988
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279855/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3162304/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.6.1744 |
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