BEL-2, an Extended-Spectrum β-Lactamase with Increased Activity toward Expanded-Spectrum Cephalosporins in Pseudomonas aeruginosa

A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalospo...

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Main Authors: Poirel, Laurent, Docquier, Jean-Denis, De Luca, Filomena, Verlinde, Annemie, Ide, Louis, Rossolini, Gian Maria, Nordmann, Patrice
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798549/
https://ncbi.nlm.nih.gov/pubmed/19884378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00859-09
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