Structure of the Heme Biosynthetic Pseudomonas aeruginosa Porphobilinogen Synthase in Complex with the Antibiotic Alaremycin

The recently discovered antibacterial compound alaremycin, produced by Streptomyces sp. A012304, structurally closely resembles 5-aminolevulinic acid, the substrate of porphobilinogen synthase. During the initial steps of heme biosynthesis, two molecules of 5-aminolevulinic acid are asymmetrically c...

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Bibliographische Detailangaben
Hauptverfasser: Heinemann, Ilka U., Schulz, Claudia, Schubert, Wolf-Dieter, Heinz, Dirk W., Wang, Yang-G., Kobayashi, Yuichi, Awa, Yuuki, Wachi, Masaaki, Jahn, Dieter, Jahn, Martina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798535/
https://ncbi.nlm.nih.gov/pubmed/19822707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00553-09
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