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Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1

Ebola virus initially targets monocytes and macrophages, which can lead to the release of proinflammatory cytokines and chemokines. These inflammatory cytokines are thought to contribute to the development of circulatory shock seen in fatal Ebola virus infections. Here we report that host Toll-like...

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Bibliografske podrobnosti
Main Authors: Okumura, Atsushi, Pitha, Paula M., Yoshimura, Akihiko, Harty, Ronald N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798428/
https://ncbi.nlm.nih.gov/pubmed/19846529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01462-09
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