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A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry

Ebolavirus (EBOV) entry into cells requires proteolytic disassembly of the viral glycoprotein, GP. This proteolytic processing, unusually extensive for an enveloped virus entry protein, is mediated by cysteine cathepsins, a family of endosomal/lysosomal proteases. Previous work has shown that cleava...

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Библиографические подробности
Главные авторы: Wong, Anthony C., Sandesara, Rohini G., Mulherkar, Nirupama, Whelan, Sean P., Chandran, Kartik
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798398/
https://ncbi.nlm.nih.gov/pubmed/19846533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01832-09
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