Dual Mechanism of Impairment of Interleukin-7 (IL-7) Responses in Human Immunodeficiency Virus Infection: Decreased IL-7 Binding and Abnormal Activation of the JAK/STAT5 Pathway

Interleukin-7 (IL-7) plays a central role in controlling the homeostasis of both naive and long-term-memory CD4(+) T cells. To better understand how human immunodeficiency virus (HIV) perturbs CD4(+) T-cell homeostasis, we performed a detailed analysis of IL-7R expression, IL-7 binding, and IL-7-dep...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Juffroy, Olivier, Bugault, Florence, Lambotte, Olivier, Landires, Ivan, Viard, Jean-Paul, Niel, Loïc, Fontanet, Arnaud, Delfraissy, Jean-François, Thèze, Jacques, Chakrabarti, Lisa A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2010
נושאים:
Pathogenesis and Immunity
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798395/
https://ncbi.nlm.nih.gov/pubmed/19864382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01475-09
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