Extrachromosomal Histone H2B Mediates Innate Antiviral Immune Responses Induced by Intracellular Double-Stranded DNA

Fragments of double-stranded DNA (dsDNA) forming a right-handed helical structure (B-DNA) stimulate cells to produce type I interferons (IFNs). While an adaptor molecule, IFN-β promoter stimulator 1 (IPS-1), mediates dsDNA-induced cellular signaling in human cells, the underlying molecular mechanism...

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Main Authors: Kobiyama, Kouji, Takeshita, Fumihiko, Jounai, Nao, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Ishii, Ken J., Kawai, Taro, Sasaki, Shin, Hirano, Hisashi, Ishii, Norihisa, Okuda, Kenji, Suzuki, Koichi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798368/
https://ncbi.nlm.nih.gov/pubmed/19906922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01339-09
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