Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

A series of nonpeptide somatostatin agonists which bind selectively and with high affinity to somatostatin receptor subtype 2 (sst2) have been synthesized. One of these compounds, L-054,522, binds to human sst2 with an apparent dissociation constant of 0.01 nM and at least 3,000-fold selectivity whe...

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Detalhes bibliográficos
Main Authors: Yang, Lihu, Berk, Scott C., Rohrer, Susan P., Mosley, Ralph T., Guo, Liangqin, Underwood, Dennis J., Arison, Byron H., Birzin, Elizabeth T., Hayes, Edward C., Mitra, Sudha W., Parmar, Rupa M., Cheng, Kang, Wu, Tsuei-Ju, Butler, Bridgette S., Foor, Forrest, Pasternak, Alexander, Pan, Yanping, Silva, Maria, Freidinger, Roger M., Smith, Roy G., Chapman, Kevin, Schaeffer, James M., Patchett, Arthur A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27982/
https://ncbi.nlm.nih.gov/pubmed/9724791
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