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The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer
Poly(ADP-ribose) polymerase-1 (PARP-1) is an important novel target in cancer therapy. This enzyme is essential in the repair of single-stranded breaks in DNA via the base excision repair pathway. Drugs which inhibit PARP are emerging as a promising new class of anticancer agents particularly effect...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Hindawi Publishing Corporation
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2798102/ https://ncbi.nlm.nih.gov/pubmed/20049345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/151750 |
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