Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes

OBJECTIVE: Mutations in the HNF1A gene are the most common cause of maturity-onset diabetes of the young (MODY). There is a substantial variation in the age at diabetes diagnosis, even within families where diabetes is caused by the same mutation. We investigated the hypothesis that common polygenic...

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Main Authors: Lango Allen, Hana, Johansson, Stefan, Ellard, Sian, Shields, Beverley, Hertel, Jens K., Ræder, Helge, Colclough, Kevin, Molven, Anders, Frayling, Timothy M., Njølstad, Pål R., Hattersley, Andrew T., Weedon, Michael N.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2010
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797932/
https://ncbi.nlm.nih.gov/pubmed/19794065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0555
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