Functional role of cysteine-146 in Escherichia coli thymidylate synthase.
Analysis of mutant Escherichia coli thymidylate synthases (EC 2.1.1.45) with various amino acids substituted for cysteine at position 146 revealed the cysteine to be involved in the binding of 2'-deoxyuridylate as well as initiating the catalytic process. The substitution of a serine or alanine resi...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
1988
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279793/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3278315/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.5.1472 |
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