Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

Plasmodium parasites lacking plasmepsin 4 (PM4), an aspartic protease that functions in the lysosomal compartment and contributes to hemoglobin digestion, have only a modest decrease in the asexual blood-stage growth rate; however, PM4 deficiency in the rodent malaria parasite Plasmodium berghei res...

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Autori principali: Spaccapelo, Roberta, Janse, Chris J., Caterbi, Sara, Franke-Fayard, Blandine, Bonilla, J. Alfredo, Syphard, Luke M., Di Cristina, Manlio, Dottorini, Tania, Savarino, Andrea, Cassone, Antonio, Bistoni, Francesco, Waters, Andrew P., Dame, John B., Crisanti, Andrea
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2010
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797883/
https://ncbi.nlm.nih.gov/pubmed/20019192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090504
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